Duane Reed has been performing music since the age of 8, and comedy for 15 years. He was a long time member of the comedy trio "No Fun Intended," and briefly of the improv group "Over the Edge."

He sings and plays, keyboards, guitar, bass guitar, dumbeg, tabla, and miscellaneous percussion and makes odd sounds on the vocal cords.

His vocal and instrumental skill were used in the video game "Food Chain."